Macrophages,
integral to the innate immune system, are involved in numerous disease and
injury models due to their unique ability to interact with neighboring cells.
Consequently, macrophage cell therapy has become a promising approach. However,
these cells can quickly alter their phenotype in response to local cues, often
assuming an undesired state. Thus, maintaining their phenotype becomes critical
in cell therapy. Our laboratory uses microparticles to intrinsically control
this, even against external stimuli. In this work, we explored the effects of
particle size on drug release kinetics and phenotype and screened potential
drugs candidates for macrophage cell therapy in fibrotic models.
