The current standard of care for breast cancer screening is a combination ofmammography, clinical breast exams, and magnetic resonance imaging (MRI).MRI imaging is extremely valuable in cases with dense or scarred breast tissue;however, the integration of MRI is often not covered by insurance for screeningpurposes and is, therefore, often not conducted. Radiographic alternatives toMRI are avoided due to the risk associated with the increase exposure dose.Volumetric ultrasound imaging, while inadequate for standalone screening, is apotential solution for complex screening cases if the modality can be fused withmammography projections. The additional information provided by volumetricultrasound allows for clearer discrimination between soft tissues possessing sim-ilar radiographic density. This project aims to fuse volumetric ultrasound withmammography projections by developing a new registration algorithm. Thisalgorithm reduces the dimensionality of the volumetric ultrasound to that ofthe target mammography projection and subsequently employs a mutual in-formation based similarity metric to frame the data fusion as an optimizationproblem.




